The Second Golden Age of Glycomics: From Functional Glycomics to Clinical Applications

Advancing glycomics: implementation strategies at the consortium for functional glycomics.

Glycomics-an integrated approach to study structure-function relationships of complex carbohydrates (or glycans)-is an emerging field in this age of post-genomics. Realizing the importance of glycomics, many large scale research initiatives have been established to generate novel resources and technologies to advance glycomics. These initiatives are generating and cataloging diverse data sets n...

Functional glycomics and glycobiology: an overview.

Glycomics is the study of the biological role of glycans and glycoconjugates, including glycoproteins, glycolipids, proteoglycans, and of protein-glycan interactions. This chapter outlines the scope of functional glycomics, from biological/biomedical significance to technology development.

Glycomics Using Mass Spectrometry

Mass spectrometry (MS), which has advanced rapidly in recent years, is expected to become the tool of choice for high-throughput analysis of relationships between structures and functions of glycans. The structural analysis of glycans using MS employs a number of methods for pretreatment, derivatization, and interpretation. However, since none of these are universally applicable, researchers ha...

Glycomics Hits the Big Time

Cells run on carbohydrates. Glycans, sequences of carbohydrates conjugated to proteins and lipids, are arguably the most abundant and structurally diverse class of molecules in nature. Recent advances in glycomics reveal the scope and scale of their functional roles and their impact on human disease.

Using Bioinformatics to Spearhead the Glycomics Revolution